Add time:07/27/2019 Source:sciencedirect.com
Biologically active photoaffinity labeled analogues of taxol (6, 8 and 9) have been synthesized utilizing (3R,4S)-3-hydroxy-4-phenyl-2-azetidinones, produced via the ester enolate-imine cyclocondensation reaction, and the diterpene baccatin III (2). Photoaffinity label 8 proved to be the most active taxol photoaffinity label synthesized to date in addition to having the most similar structure to that of the parent, taxol.
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