Add time:07/25/2019         Source:sciencedirect.com

Two new methods to ensure selective alkylation of the N4 of 2-piperazinecarboxylic acid to give 4-(3-phosphonopropyl)-2-piperazinecarboxylic acid (CPP, 1) are reported. CPP can be conveniently prepared using a copper chelate to selectively protect the N1 position during alkylation. A second procedure uses methyl-4-BOC-1-CBZ-2-piperazinecarboxylate 5 as a versatile intermediate, which was further elaborated to CPP.

We also recommend Trading Suppliers and Manufacturers of METHYL N-4-BOC-N-1-CBZ-2-PIPERAZINECARBOXYLATE (cas 126937-42-6). Pls Click Website Link as below: cas 126937-42-6 suppliers