Add time:07/25/2019         Source:sciencedirect.com

Background/aimPyrimidine is found as a core structure in a large variety of compounds that exhibit important biological activity. Specifically, 2,4,5,6-tetrasubstituted dihydropyrimidines have shown potent antimycobacterial activity. The use of combinatorial approaches toward the synthesis of drug-like scaffolds is a powerful tool in helping to speed up drug discovery. Recently, we have developed a laboratory made para toluenesulfonic acid (PTSA) as an efficient catalyst to generate 2,4,5,6-substituted dihydropyrimidine libraries using a one-pot multicomponent reaction.

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