Add time:07/26/2019         Source:sciencedirect.com

Liquid phase fluorination of norbornene with 1-chloromethyl-4-fluoro-1,4-diazonia[2.2.2]octane bis(tetrafluoroborate)—F-TEDA resulted in the formation of two rearranged Ritter type products: 2-exo-acetamido-7-syn-fluoro norbornane and 2-exo-acetamido-7-anti-fluoro norbornane in 1:1 ratio in acetonitrile, while the presence of an external nucleophile, e.g. water or methanol resulted in formation of two additional rearranged products: 2-exo-hydroxy or methoxy -7-syn-fluoro norbornane and 2-exo-hydroxy or methoxy-7-anti-fluoro norbornane. Fluorination of cycloalkenes obeys a simple second order rate equation, relative rates close to unity were found for norbornene/cyclohexene and cyclopentene/cyclohexene pairs. Activation parameters were determined for cycloalkenes in acetonitrile–water (ΔH‡=14 kcal mol−1 and ΔS‡=−20 cal mol−1K−1 for norbornene), while the Winstein–Grunwald solvent polarity variation had negligible effect.

We also recommend Trading Suppliers and Manufacturers of 1-Methoxy-1-cyclopentene (cas 1072-59-9). Pls Click Website Link as below: cas 1072-59-9 suppliers