Add time:07/26/2019         Source:sciencedirect.com

Class I phosphoinositide 3-kinases (PI3Ks), particularly PI3Kγ, have become attractive drug targets for inflammatory and autoimmune disorders such as rheumatoid arthritis. Herein, we describe the synthesis and the structure–activity relationships (SAR) of a series of 2-amino-5-oxadiazolyl thiazoles, culminating in the identification of 8j (TASP0415914), an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). TASP0415914 demonstrated good potency in a cell-based assay and, furthermore, exhibited in vivo efficacy in a collagen induced arthritis (CIA) model in mice after oral administration.

We also recommend Trading Suppliers and Manufacturers of 2-(1,2,4-Oxadiazol-3-yl)pyridine (cas 13389-59-8). Pls Click Website Link as below: cas 13389-59-8 suppliers