Add time:07/11/2019         Source:sciencedirect.com

Publisher SummaryThe chapter discusses later work on glycosiduronic acids and their derivatives from chemical point of view. As a consequence of the biological importance and general interest in the chemistry of Dglucosiduronic acids, the chapter is mainly concentrated around those conjugates having D-glucuronic acid as the sugar component. The nature of protective groups on the sugar component is of the utmost importance in the synthesis of many glycosiduronic acids. Successful synthesis of a glycosiduronic acid sensitive to alkaline or acidic conditions, or both, depends largely on the conditions under which the protecting groups of the sugar moiety can be removed after formation of the glycosidic bond. There has been considerable interest in the preparation of glucopyranuronate intermediates protected with groups readily removable under mild and non-hydrolytic conditions. The formation of β-D-glucosiduronic acids by enzymic conjugation is, in vertebrates, the most widespread of conjugation mechanisms, in which hydroxyl groups in almost any type of foreign compound are potentially capable of conjugating with D-glucuronic acids.

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