Add time:07/26/2019         Source:sciencedirect.com

A new heterocyclic reductive alkylating agent, the 2-methyl-4-chloromethyl-5-nitrothiazole, has been synthesized and could react with the 2-nitropropane anion as nucleophile, to give the 2-methyl-4-(2-methylpropenyl)-5-nitrothiazole as the major product. The reaction was shown to proceed by the SRN1 mechanism which was confirmed by the classical criteria for SRN1 reaction: the leaving group effect, the electronwithdrawing group effect and classical inhibition experiments by dioxygen, p-dinitrobenzene, cupric chloride or di-tert-butylnitroxide. This reaction has been extended to nitrocyclopentane and nitrocyclohexane anions with lower yields.

We also recommend Trading Suppliers and Manufacturers of 4-Methyl-5-nitrothiazole-2(3H)-thione (cas 13416-33-6). Pls Click Website Link as below: cas 13416-33-6 suppliers