Add time:07/26/2019 Source:sciencedirect.com
A series of new 1,4 disubstituted (1-alkyl-1H-1,2,3-triazol-4-yl)methyl-2H-chromene-3-carboxylates (4ai–4eiii) have been efficiently synthesized in moderate to excellent yields by the 1,3 dipolar cycloaddition between 2-propynyl-2H-chromene-3-carboxylates 3a–e and various alkyl azides under Cu(I) catalyzed conditions. The structures of the synthesized compounds are established based on IR, NMR, MASS Spectrometric methods and elemental analyses. The antibacterial and antifungal activities of synthesized compounds were evaluated. Compounds 4biii, 4ei, 4dii, 4ai, 4aii, 4bii showed good activity against bacterial strains and the compounds 4bi, 4eii against fungal strains.
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