Add time:07/12/2019         Source:sciencedirect.com

4-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene) amino]-N(4,6-dimethyl-2-pyrimidinyl)-benzene sulphonamide and its derivatives were synthesized by reaction of isatin and its derivatives with sulphadimidine. Their chemical structures have been confirmed by IR, 1H NMR data and elemental analysis. Investigation of anti-HIV activity of compounds were tested against replication of HIV-1 (IIIB) and HIV-2 (ROD) strains in acutely infected MT-4 cells and the activity compared with standard azidothymidine. Among the compounds tested, 4-[(1,2-dihydro-2 oxo-3H-indol-3-ylidene)amino]-N(4,6-dimethyl-2-pyrimidinyl)-benzene sulphonamide and its N-acetyl derivative were the most active compounds.

We also recommend Trading Suppliers and Manufacturers of DIMETHYL 1-(4,6-DIMETHYL-2-PYRIMIDINYL)-1H-1,2,3-TRIAZOLE-4,5-DICARBOXYLATE (cas 23951-57-7). Pls Click Website Link as below: cas 23951-57-7 suppliers