Add time:07/31/2019         Source:sciencedirect.com

Publisher SummaryThe nucleic acids comprise compounds that conform to the “nucleotide” pattern, consisting of a phosphoric ester of a N-l-deoxyglycoside; many of these compounds possess well-defined, coenzyme functions. In a narrower sense, the term is applied to polynucleotides, characterized by either D-ribose or 2-deoxy-D-erythro-pentose (“2-deoxy-D-ribose”) as the carbohydrate component. For the preparation of nucleosides, hydrolysis of ribonucleic acids is normally carried out in alkaline medium at elevated temperatures. Dilute sodium hydroxide or ammonium hydroxide has been commonly used, but lead hydroxide has been suggested as a satisfactory reagent; zinc hydroxide causes incomplete mineralization of the phosphoric acide. Boiling aqueous pyridine, however, is probably the most convenient reagent for laboratory use. The method of Bredereck and coworkers is considerably improved by separation of uridine and cytidine by ion-exchange chromatography. If it is desired to isolate only the pyrimidine nucleosides, hydrolysis of the nucleic acid may be carried out in acid medium. This process, however, entails extensive deamination of cytidine to uridine.

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