Add time:07/12/2019 Source:sciencedirect.com
Aminopeptidase N (APN) is involved in different physiological and pathological processes of tumor cells, including proliferation, invasion, apoptosis and metastasis. Herein one series of compounds derived from commercially available (1S,2S)-2-amino-1-(4-nitrophenyl) propane-1,3-diol have been designed and synthesized. Furthermore, preliminary activity evaluation showed that some compounds elicited moderate inhibitory activity against APN with compounds 10e (IC50 = 6.1 ± 0.5 μM) possessing the best efficacy, which could be used as the lead compound in the future for anticancer agents research.
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