Add time:08/02/2019         Source:sciencedirect.com

Weanling rats fed a diet containing tellurium develop a peripheral neuropathy characterized by a highly synchronous primary demyelination; this demyelination is followed closely by a period of rapid remyelination. The demyelination is related to the inhibition of squalene epoxidase activity, which results in a block in cholesterol synthesis. Expression of mRNA for the major structural proteins of PNS myelin, myelin basic protein and P0, is coordinately down-regulated during the demyelinating phase and then up-regulated during the remyelinating phase (Toews et al., J. Neurosci. Res., 26 (1990) 501–507). We now report tellurium-induced alterations in gene expression for several proteins which are not major structural components of myelin in the peripheral nervous system. Expression of mRNA for nerve growth factor receptor in sciatic nerve was very low in control animals, but was markedly up-regulated after 3–5 days of exposure to tellurium, a time corresponding to the beginning of demyelination. Levels remained elevated during the subsequent period of remyelination. Expression of mRNA for SCIP (a presumptive transcription factor) was also up-regulated in sciatic nerve following tellurium exposure, with a time course similar to that for nerve growth factor receptor. When examined as a fraction of total RNA, steady-state mRNA levels for 2′,3′-cyclic nucleotide 3′-phosphodiesterase and the myelin proteolipid protein were decreased during the demyelinating phase; however, this decrease could be largely accounted for the increased levels of total RNA. When analyzed on a ‘per nerve’ basis, steady-state mRNA levels for these two proteins were actually increased about 2-fold by 9 days after beginning tellurium exposure. Differences in alterations of mRNA levels between these two ‘myelin-related’ proteins and the two major structural proteins of PNS myelin suggest that in the PNS, 2′,3′-cyclic nucleotide 3′-phosphodiesterase and the myelin proteolipid protein may play roles distinct from their functions in CNS myelin.

We also recommend Trading Suppliers and Manufacturers of SCIP protein (cas 132052-52-9). Pls Click Website Link as below: cas 132052-52-9 suppliers