Add time:08/02/2019         Source:sciencedirect.com

A reversed-phase HPLC method was developed and validated for the determination of caffeine and potassium sorbate in a neonatal oral solution. Chromatography was performed with a 100 × 4.5 mm Spherisorb 5 μm hexyl column with a mobile phase of 12% acetonitrile in 0.1 M sodium acetate buffer pH 4.5 and ultraviolet detection at 258 nm. The method is stability indicating and there was no interference from a number of common formultion ingredients, although benzoic acid did interfere.

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