Add time:07/29/2019 Source:sciencedirect.com
A series of novel thiazolo derivatives 2–17 were synthesized by initial condensation of methyl 2-(thiazol-2-ylcarbamoyl)acetate 1 with phenyl isothiocyanate and further reactions using different organic reagents. The structures of newly synthesized compounds were confirmed by IR, 1H NMR, EIMS spectral data and elemental analysis. Initially the acute toxicity of the compounds was assayed via the determination of their LD50. All the compounds were screened for their antiarrhythmic and anticoagulant activities and they showed high antiarrhythmic activity compared with procaine amide and lidocaine as positive controls. The detailed synthesis, spectroscopic data, LD50 and pharmacological activities of the synthesized compounds were reported.
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