A short convergent synthesis of the [3.2.1]dioxabicyclooctane subunit of sorangicin A via regioselective epoxide opening-Science-Chemical Encyclopedia-lookchem

A short convergent synthesis of the [3.2.1]dioxabicyclooctane subunit of sorangicin A (cas 100415-25-6) via regioselective epoxide opening
Add time:07/28/2019 Source:sciencedirect.com

In this paper, we disclose the synthesis of the dioxabicyclo[3.2.1]octane subunit of the potent antibiotic sorangicin A (cas 100415-25-6). The synthesis was achieved in a convergent manner in 8 steps. Regio- and stereoselective intermolecular epoxide opening, ring-closing metathesis and iodo-etherification are key steps. cis-2-Butene diol has been employed as a common staring material.

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