Add time:07/28/2019         Source:sciencedirect.com

Publisher SummaryThis chapter discusses maprotiline hydrochloride. Maprotiline hydrochloride occurs as a white to off-white, odorless, fine, crystalline powder. Maprotiline hydrochloride is polymorphic and known to exhibit several crystal forms. A typical production batch is a mixture with varying ratios of crystal form A and B. The two crystal forms show no difference in solubility characteristics at room and physiological temperatures. The existence of polymorphism has also been shown by differential scanning calorimetry. A typical batch of maprotiline hydrochloride frequently exhibits two melt endotherms indicating the presence of two crystal forms. Maprotiline hydrochloride is freely soluble in methanol and chloroform, slightly soluble in water, and practically insoluble in isooctane. Maprotiline hydrochloride is best identified by: infrared absorption, ultraviolet absorption, and a test for chloride.

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