Add time:07/29/2019         Source:sciencedirect.com

The synthesis and the kinetics of the synthesis of d4-succinic anhydride from succinic anhydride and d1-acetic acid, catalyzed by sodium acetate, are presented. The results show that the conversion is both base and solvent catalyzed, suggesting that the deuteration may occur through the enolization of succinic anhydride. The synthesis is faster and simpler than previous methods and makes use of relatively accessible and inexpensive materials.

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