Add time:07/17/2019 Source:sciencedirect.com
A highly efficient and environmentally benign protocol has been developed for the construction of various potentially biologically active N-methyl-2-nitro-aryl-1H-benzo[f]chromen-3-amine derivatives using one-pot, multi-component cascade reaction of various naphthalen-2-ol, aldehydes, and (E)-N-methyl-1-(methylthio)-2-nitroethenamine under catalyst-free conditions in the presence of green solvent medium (ethanol–water) is described. The significant features of this protocol are short reaction times, provide excellent yields, avoidance of toxic solvents and catalysts, no column chromatographic purification, atom-economy and uses ethanol–water as a green solvent which is considered to be relatively environmentally benign. This is the first example of the condensation of naphthalen-2-ol, aldehydes, and (E)-N-methyl-1-(methylthio)-2-nitroethenamine to provide a novel series of 1H-benzo[f]chromen-3-amine derivatives.
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