Add time:08/01/2019         Source:sciencedirect.com

α-Bromo β-hydroxy ester 2 was prepared in a preparative scale by a 96 : 4 enantioselective aldol reaction of t-butyl bromoacetate with isobutyraldehyde and converted efficiently to either (2S,3S)- or (2R,3S)-3-hydroxyleucine (7 or 11).

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