Add time:07/29/2019         Source:sciencedirect.com

The asymmetric syntheses of (R)-(+)- and (S)-(−)-O-methylbharatamine were performed using the lateral metallation strategy, in which (R)- and (S)-phenylalaninol were applied as chiral auxiliaries. The addition reaction of chiral o-toluamide carbanion to 6,7-dimethoxy-3,4-dihydroisoquinoline proceeded with a simultaneous cyclization reaction, giving both enantiomers of 2,3-dimethoxy-8-oxoberbine in good yield (76%) with high enantioselectivity (99% ee). Lithium aluminum hydride reduction of each enantiomer led to (R)-(+)- and (S)-(−)-O-methylbharatamine without loss of enantioselectivity.

We also recommend Trading Suppliers and Manufacturers of (R)-2-Methyl-1-(o-tolyl)propan-1-aMine hydrochloride (cas 100485-64-1). Pls Click Website Link as below: cas 100485-64-1 suppliers