Add time:07/29/2019         Source:sciencedirect.com

The synthesis of a mannosylated carrier used as a drug delivery system to target specifically an antileishmanial drug allopurinol riboside [4-hydroxy-1-β-D-ribofuranosyl-1H-pyrazolo(3,4-d) pyrimidine] into Leishmania donovani infected macrophages via their membrane lectin is described. The synthetic construct is made of a poly-L-lysine backbone, partially acylated with δ-gluconolactone to enhance its water-solubility and substituted with glycyl-glycine as a spacer arm. O-p-phenylisothiocyanate-5′-phosphodiester derivatives of allopurinol riboside and of inosine were synthesized and attached to the spacer arm, then the remaining spacer arms were substituted by reaction with phenyl acetate mannosyl residues.

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