Add time:08/05/2019         Source:sciencedirect.com

The AB ring system 2 of aklavinone (cas 16234-96-1) 1 was obtained using a chemoenzymatic protocol. Key steps are the stereoselective addition of lithium enolate of ethyl acetate to ketone 13 and the intramolecular Friedel-Crafts reaction to give tetralin 17.

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