Add time:07/29/2019         Source:sciencedirect.com

The tributylphosphane-promoted [3 + 2] annulation reactions of 3-hydroxyoxindoles with acrylates have been developed to give a variety of pharmaceutically attractive spirocyclic oxindole-lactone derivatives in good to excellent yields. The structures of all the compounds were confirmed by 1H NMR, 13C NMR and HRMS. This metal-free procedure features low costs of the reagents and materials, mild reaction conditions, non-toxicity and easy handling for scalable synthesis.

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