Base-catalyzed synthesis of bicyclic 4-aminopyrimidines from the reaction of dinitriles with mononitriles-Science-Chemical Encyclopedia-lookchem

Base-catalyzed synthesis of bicyclic 4-aminopyrimidines from the reaction of dinitriles with mononitriles
Add time:08/02/2019 Source:sciencedirect.com

A convenient method for the synthesis of bicyclic 4-aminopyrimidines is described, involving the reaction of dinitriles with mononitriles in the presence of catalytic potassium tert-butoxide. These reactions proceed via the Thorpe–Ziegler cyclization of the dinitrile to form an intermediate β-cyanoenamine, which then undergoes annulation with the mononitrile in situ.

We also recommend Trading Suppliers and Manufacturers of 4-(2-Cyanoethyl)benzonitrile (cas 18176-72-2). Pls Click Website Link as below: cas 18176-72-2 suppliers

Prev:Adsorptive properties of N-2-cyanoethyl-N-methylaminosilica in high-performance liquid chromatography
Next: A synthetic procedure for the preparation of oligonucleotides without using ammonia and its application for the synthesis of oligonucleotides containing 0-4-alkyl thymidines.)

Click to view details

Encyclopedia