Chemical synthesis and biological activity of novel brominated 7-deazaadenosine-3′,5′-cyclic monophosphate derivatives-Science-Chemical Encyclopedia-lookchem

Chemical synthesis and biological activity of novel brominated 7-deazaadenosine-3′,5′-cyclic monophosphate derivatives
Add time:07/11/2019 Source:sciencedirect.com

Synthetic derivatives of cyclic adenosine monophosphate, such as halogenated or other more hydrophobic analogs, are widely used compounds, to investigate diverse signal transduction pathways of eukaryotic cells. This inspired us to develop cyclic nucleotides, which exhibit chemical structures composed of brominated 7-deazaadenines and the phosphorylated ribosugar. The synthesized 8-bromo- and 7-bromo-7-deazaadenosine-3′,5′-cyclic monophosphates rank among the most potent activators of cyclic nucleotide-regulated ion channels as well as cAMP-dependent protein kinase. Moreover, these substances bind tightly to exchange proteins directly activated by cAMP.

We also recommend Trading Suppliers and Manufacturers of 8-BROMOADENOSINE 5'-MONOPHOSPHATE (cas 23567-96-6). Pls Click Website Link as below: cas 23567-96-6 suppliers

Prev:Synthesis of novel 2, 5-dihydrofuran derivatives and evaluation of their anticancer activity
Next: Synthesis, photochemistry and application of (7-methoxycoumarin-4-yl)methyl-caged 8-bromoadenosine cyclic 3′,5′-monophosphate and 8-bromoguanosine cyclic 3′,5′-monophosphate photolyzed in the nanosecond time region)

Click to view details

Encyclopedia