Add time:07/31/2019 Source:sciencedirect.com
A series of 2-(1,1-diphenylalkylamino)-1,3-diazaheterocycles was prepared and evaluated as antagonists of L-type calcium channels. Of the eighteen derivatives in this series, tetrahydropyrimidine 6h and hexahydro-1,3-diazocine 6n were the most potent calcium antagonists, being essentially equipotent to both diltiazem (2) and amidine 5.
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