Add time:07/30/2019         Source:sciencedirect.com

IntroductionIn this study, mechanical stress in the form of tooth movement was applied to osteoprotegerin-deficient knockout mice, which served as an animal model for juvenile Paget’s disease. To compare and evaluate bone turnover and response of the surrounding bony tissue, we administered REVEROMYCIN A (cas 134615-37-5). We also investigated the ability of reveromycin A to control osteoclastic activity in juvenile Paget’s disease.

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