Add time:07/30/2019         Source:sciencedirect.com

1.1. Evidence was obtained that sarcosine: (a) partially inhibits actinomycin formation by Streptomyces chrysomallus and Streptomyces antibiotics and (b) markedly inhibits the incorporation of proline, hydroxyproline and oxoproline into the antibiotic peptides.2.2. Experiments with (N-Me-14C)- and (1-14C)-labeled sarcosine have revealed that sarcosine is directly incorporated into the various actinomycins synthesized by S. chrysomallus and S. antibiotics.3.3. Radioisotope dilution experiments to establish a precursor-product relationship between glycine and sarcosine have proved to be inconclusive due to competition by the amino acids for entry into or exit from the cells.4.4. It is concluded that free or enzyme-bound glycine is first methylated and that the sarcosine formed is then incorporated into the actinomycin peptide.

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