Add time:07/30/2019         Source:sciencedirect.com

3-Hydroxy-3-methyl-1-thionoglutaryl-coenzyme A, a dithioester analog of 3-hydroxy-3-methylglutaryl-CoA, has been enzymatically synthesized using the HMG-CoA synthase catalyzed condensation of acetyl-CoA with 3-oxo-1-thionobutyryl-CoA. HMGdithio-CoA is a potent inhibitor of Pseudomonas mevalonii HMG-CoA reductase. Inhibition was mainly competitive with respect to HMG-CoA with a Kis of 0.086 ± .01 μm and noncompetitive with respect to NADH with a Kis of 3.7 ± 1.5 μm and a Kii of 0.65 ± .05 μm in the presence of 110 μm (R,S)-HMG-CoA.

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