Add time:08/02/2019         Source:sciencedirect.com

Herein we describe the further improvement of our in-house developed firefly bioluminescence assay system for the determination of inhibition of protein phosphatase (PP). The advantage with the new system is higher sensitivity as well as being time and sample efficient. The inhibition activity of TAUTOMYCIN (cas 109946-35-2) with PP1γ was determined using the upgraded test system and Ki was found to be 4.5 nM, which compare favorably with the activity reported previously by others using different methods. The test system was then used in order to determine the activity of nine tautomycin (TTM) photoaffinity probes. One of the TTM photoaffinity probes (anti-10) was found to possess higher activity than the natural product itself with a Ki of 3.4 nM, while the remaining photoaffinity probes were found to possess Ki in the range of 8.0–213 nM.

We also recommend Trading Suppliers and Manufacturers of TAUTOMYCIN (cas 109946-35-2). Pls Click Website Link as below: cas 109946-35-2 suppliers