Add time:07/30/2019         Source:sciencedirect.com

Sodium naphthalenide effects removal of 2′-, 3′-, or 5′-O-tosyl groups from the sugar, and 2-, 6-, or 8-halogens from purine nucleosides. An improved tosyl protection strategy was developed for the synthesis of 9-(3-deoxy-3-fluoro-β-D-xylofuranosyl)adenine from 2′,5′-di-O-tosyladenosine.

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