Add time:07/31/2019         Source:sciencedirect.com

A highly selective and sensitive colorimetric sensor for the determination of nabumetone (NAB) based on the aggregation of the thiolated β-cyclodextrin (Tβ-CD) functionalized gold nanoparticles (Au-NPs) with NAB in the presence of polyvinylpyrrolidone (PVP) was developed. Thiolated β-cyclodextrin bonds to the surface of Au-NPs and forms a complex with NAB. The presence of PVP changed the NAB:Tβ-CD complex to the NAB:(Tβ-CD)2:PVP ternary complex which resulted in the aggregation of the Au-NPs. As a result of this aggregation, the localized surface plasmon resonance (LSPR) band of Au-NPs around 520 nm decreased and a new red shifted band at 650 nm appeared which gradually increased with an increase in the NAB concentration. Under the optimized conditions, the calibration curve derived from the ratio of absorbance intensity at 650 nm to the original wavelength of 520 nm against NAB concentration was linear in the concentration range of 1–120 μg L−1. The limits of detection (LOD) and quantification (LOQ) were 0.2 and 0.7 μg L−1, respectively. The relative standard deviation at 20 μg L−1 of NAB was found to be 3.1%. The selectivity of the method was demonstrated through the analysis of the synthetic samples containing the major interference compound reported in the literature. Finally, the method was successfully applied to the determination of NAB in pharmaceutical, urine and wastewater samples.

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