Add time:07/12/2019         Source:sciencedirect.com

The oxidation of methionine-CH3C14 and methionine-2-C14 to respiratory CO2 was greater in the female than in the male rat. The reverse was true for ethionine-C2H5-C14 and ethionine-2-C14. The presence of ethionine in the diet increased the oxidation of methionine to respiratory CO2, and the presence of methionine in the diet increased the oxidation of ethionine to CO2. The extent of oxidation of ethionine and methionine in the male and female rat is inversely related to the extent of incorporation of the labeled carbons of the two amino acids into tissue components, such as choline, creatine, and ethionine and methionine of the proteins. In vitro, S-adenosyl-l-methionine depressed the transfer of the ethyl group of S-adenosyl-l-ethionine to choline and creatine, and S-adenosyl-l-ethionine depressed the transfer of the methyl group of S-adenosyl-l-methionine to choline and creatine. These results are discussed in the light of common metabolic path of ethionine and methionine in the rat, being qualitatively similar in both sexes. The quantitative differences in the extent of metabolic disposal of methionine and ethionine in the male and female rat may have some relationship to reported differences in the responses to ethionine in the two sexes.

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