Add time:07/31/2019         Source:sciencedirect.com

Publisher SummaryThis chapter discusses strychnine. Strychnine is an indole alkaloid that occurs in numerous strychnos plants of the family Loganiaceae. Strychnine was first discovered in 1817 by the French Pharmacists, Pierre Pelletier, and Joseph Caventou; these workers were also responsible for the first isolation of brucine in 1819. Structural investigations of strychnine were begun by Hanssen and Tafel and continued by Leuchs, Perkin, Robinson, Wieland, and Woodward. Finally, the structure of strychnine was established by Robinson and co-workers in 1946 and confirmed by X-ray crystallographic analysis and total synthesis by Woodward. Strychnine is used as a rodenticide for destroying agricultural rodents and predatory animals. Occasionally, domestic animals and man are poisoned by this agent. The infrared (IR) spectrum of strychnine as KBr disc was recorded on a Perkin Elmer 580 B Infrared Spectrometer to which an infrared data station is attached.

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