Add time:07/31/2019         Source:sciencedirect.com

A spectrophotometric analysis of the UV-spectrum of 4-methoxy-2-[2-hydroxy-3(4-phenyl-1-piperazinyl)]propyl-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c]pyridine (I) in 0.01 M HCl was performed by determining the values of specific absorption coefficients at the following analytical wavelengths: 224, 285 and 348 nm. The separation by means of TLC of compound I and of its five decomposition products was also studied. Silica gel coated plates (60 F254) were used and the mobile phase was consisted of butanol–acetic acid (1.05 kg/l)–water (80:12:30, v/v/v). The HPLC method (LiChrosorb® 100 RP-18 column 250×4.0 mm I.D., dp=5 μm; mobile phase: acetonitrile–0.01 M phosphate buffer (H3PO4+KH2PO4; pH 3) (50:50, v/v-phase A) or (30:70, v/v-phase B) was validated by determination of the following parameters: selectivity, precision, linearity, stability of the analite and LOD as well as LOQ. Kinetic studies of the decomposition process of I in both acidic and alkaline environments indicate instability of the imide group.

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