Add time:08/01/2019         Source:sciencedirect.com

The efficient detection of dopamine (DA) is extremely important for human health. In this paper, gold nanoclusters (AuNCs) modified by glutathione (GSH) and 11-mercaptoundecanoic acid (11-MUA) were synthesized at room temperature. The amino pillar[5]arene (AP5) can be loaded onto the surface of AuNCs through classical EDC/NHS condensation reaction to obtain the AP5-AuNCs nanocomposite. The proposed AP5-AuNCs fluorescent probe is designed for DA detection. The fluorescence of AP5-AuNCs probe can be quenched effectively by electron transfer of oxidized DA. The linear range of DA was 5–700 nM and the detection limit was 1.5 nM. The probe was applied to the determination of DA in human urine samples, the recovery rate of DA was 98.97–100.29%. The relative standard deviation (RSD) was in the range of 1.56–2.31. This indicated that the present method can be applied to detection of dopamine in human urine samples.

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