Add time:08/01/2019         Source:sciencedirect.com

4,5-Dihydrofuran-3-carbonitriles 3a–i were obtained through oxidative cyclizations of 3-oxo-3-phenylpropanenitrile 1a, 3-oxo-3-thien-2-ylpropanenitrile 1b, 3-(2-furyl)-3-oxopropanenitirle 1c, 3-(1-benzofuran-2-yl)-3-oxopropanenitrile 1d, and 4,4-dimethyl-3-oxopropanenitrile 1e mediated manganese(III) acetate with 1,1-diphenyl-1-butene 2a and 1,2-diphenyl-1-pentene 2b. The treatments of these 3-oxopropanenitriles with 2-thienyl substituted alkenes such as 2-[(E)-2-phenylvinyl]thiophene 2c, 2-[(E)-1-methyl-2-phenylvinyl]thiophene 2d, and 2-(1-phenylvinyl)thiophene 2e formed 5-(2-thienyl)-4,5-dihydrofuran-3-carbonitriles 3j–r in good yields (45–93%). As a result, 2-thienyl substituted alkenes formed products in higher yields than phenyl substituted derivatives.

We also recommend Trading Suppliers and Manufacturers of 5-(THIEN-2-YL)THIOPHENE-2-CARBONITRILE (cas 16278-99-2). Pls Click Website Link as below: cas 16278-99-2 suppliers