Add time:08/03/2019         Source:sciencedirect.com

Publisher SummaryThis chapter discusses the physical properties, chemical properties, synthesis, stability, pharmacokinetics and metabolism, and analytical methods of chlorthalidone. Chlorthalidone is an antihypertensive diuretic used in the treatment of edema associated with congestive heart failure. It is the active component in Hygroton, Regroton, and Demi–Regroton. The drug shows long lasting diuretic actions similar to those of other thiazide diuretics such as chlorothiazide. It is absorbed slowly from the gastrointestinal tract and is excreted largely as unchanged drug. The chapter provides the infrared absorption spectrum of chlorthalidone obtained from potassium bromide dispersion. The spectrum was recorded on a Perkin–Elmer 621 grating infrared spectrophotometer. The solubility of chlorthalidone in a variety of solvents has been determined. Chlorthalidone has been found to be freely soluble in dimethylacetamide (DMA), dimethylformamide (DMF), dimethylsulfoxide (DMSO), and methanol.The solubility reported for chlorthalidone in ethanol varies from slightly soluble at room temperature to soluble in warm ethanol.

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