Add time:07/13/2019         Source:sciencedirect.com

A highly stereoselective [3 + 2] cycloaddition for constructing the chiral spiro-cyclopentene/cyclopentadiene-oxindole skeletons is developed. Under the mild reaction conditions, the straightforward cyclization of isatin-derived MBH carbonates and β,γ-unsaturated α-keto esters involving a chiral tertiary amine catalyst provides the corresponding spirooxindole derivatives with an extraordinary level of diastereo- and enantioselectivities. Further synthetic utility of this protocol is demonstrated by the gram-scale experiment and functional transformation of the synthetic compound into other structurally diverse spirooxindole.

We also recommend Trading Suppliers and Manufacturers of 2-Methoxy-α-[(2E)-3-methoxy-5-oxo-4-phenylfuran-2(5H)-ylidene]benzeneacetic acid methyl ester (cas 22628-25-7). Pls Click Website Link as below: cas 22628-25-7 suppliers