Add time:08/10/2019         Source:sciencedirect.com

Publisher SummaryThis chapter discusses the antioxidant activity of Nitecapone (cas 116313-94-1) and its analog OR-1246. The effect of structural modification on antioxidant action is also described. Nitecapone is an effective peripherally acting inhibitor of catechol O-methyl-transferase. Nitecapone scavenges superoxide, hydroxyl, and peroxyl radicals generated either in solution or in membranes, protects membranes from lipid peroxidation, recycles vitamin E through a reaction with ascorbate, and inhibits xanthine oxidase activity. The compound also form a reversible adduct with glutathione, and protect this thiol from oxidative depletion. Nitecapone exerts gastroprotective effects in various models of gastric and duodenal ulcers, and it is being evaluated in a clinical study as an antiulcer drug. Although the stimulation of duodenal bicarbonate secretion mediated by nitecapone through the inhibition of catechol O-methyltransferase activity could explain the gastroprotective effect, the antioxidant properties of the molecule could also contribute to this protection. The chapter describes the methods used to assess the effects of the distinctive structural and physicochemical properties of nitecapone and OR-1246 on their respective antioxidant activities.

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