Add time:08/02/2019         Source:sciencedirect.com

The catalytic activity of benzoic acid could be increased by introducing a hydrogen bond donor group at the ortho-position. Preliminary DFT calculation indicated that the activation of CC double bond was realized by the action of both the carboxyl group and the hydrogen bond donor. The amino group was brought to the activated CC bond by the interaction between the carboxyl oxygen and amino proton. This interaction also increased the nucleophilicity of the amino group. Thus, in the presence of 20 mol % of 2-(trifluoromethanesulfonamido)benzoic acid, intramolecular hydroamination of unfunctionalized olefins gave the corresponding products in up to 95% isolated yields.

We also recommend Trading Suppliers and Manufacturers of 2-[(4-Chlorobenzyl)amino]benzoic acid (cas 14345-04-1). Pls Click Website Link as below: cas 14345-04-1 suppliers