Add time:08/02/2019         Source:sciencedirect.com

Acute injection of the cannabinoid agonist HU 210 (6.25–100 μgkg, i.p.) dose-dependently inhibited rat locomotor activity and rearing, while subchronic treatment with the drug (once daily for 7 days) at the same doses only diminished locomotion. Acute but not subchronic administration of HU 210 (12.5–50 μgkg, i.p.) potently counteracted acute and subchronic cocaine (15 mgkg, i.p.)-induced hyperlocomotion and enhanced rearing. The acute cannabinoid (6.25–100 μgkg, i.p.) also inhibited locomotor activity, stereotyped behaviour and shaking elicited by the D1D2 agonist CQP 201-403 (500 μgkg, i.p.). On the contrary, subchronic treatments with HU 210 enhanced CQP 201-403-induced locomotor activity and potently stimulated escape attempts. Discussion centers on the influence of cannabinoids on experimental models of psychosis

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