Add time:08/03/2019 Source:sciencedirect.com
We prepared a series of new N-[2-(4-substitutedpiperazin-1-yl)ethyl]-1-(n-butyl or phenyl)-2,5-dimethyl-3,4-pyrroledicarboximides 3 and the related products 4 and 5, nine representatives of which were evaluated as potential analgesic agents in an animal model (mice). The new pyrroledicarboximides were not toxic (LD50 ≥ 1466 mg/kg) and eight of them displayed analgesic activity ~1.5–5 times superior to that of ASA in the writhing test. However, the compounds were found to be unstable in methanol solution and in dilute bases (methanol/NaOMe). The S–A relationship is discussed.
We also recommend Trading Suppliers and Manufacturers of ethyl 4-hydroxy-4-phenylpiperidine-1-carboxylate (cas 16332-22-2). Pls Click Website Link as below: cas 16332-22-2 suppliers
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View