Add time:08/02/2019         Source:sciencedirect.com

A number of methods are available for evaluating the potential of chemical agents to induce cancer in test animals. Recent use of SIMCA pattern recognition in structure-biological activity studies suggests that this method may be useful in making such evaluations. In this report this method is used to estimate the potential of a number of N-nitroso compounds to induce tumors in the rat. The data treatment and estimation results are consistent with the chemistry of these substances.

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