Add time:08/03/2019 Source:sciencedirect.com
The anticonvulsant activity of ester- and amide-type lipid conjugates of glycine and N-benzyloxycarbonylglycine (Z-glycine) was evaluated in the maximal electroshock (MES) test and the strychnine test. Regardless of the type of the conjugates the Z-glycine derivatives were always more potent than the corresponding glycine derivatives. The amide lipids proved to be more active than the ester derivatives. While the lipid carriers with straight chain fatty acids that did not contain glycine or Z-glycine did not show anticonvulsant activity in either of the tests applied, lipid carriers containing aromatic or aliphatic rings in the acids displayed activity although lower than the conjugates containing glycine or Z-glycine. The lipid conjugates did not display significant binding to the strychnine-sensitive glycine receptor or to the strychnine-insensitive NMDA receptor.
We also recommend Trading Suppliers and Manufacturers of N-(Benzyloxycarbonyl)glycine tert-butyl ester (cas 16881-32-6). Pls Click Website Link as below: cas 16881-32-6 suppliers
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View