Add time:08/03/2019         Source:sciencedirect.com

Using polyethylene oxide (PEO) with 4-amino-N-(2-pyrimidinyl) benzene sulfonamide (APBS) and hydroxyl at both ends as parent compounds, 5-fluorouracil (5-Fu) and nitrogen mustard (N-Mu) were successfully grafted on PEO end respectively by esterifying reaction of acyl chloride derivatives of 5-Fu and N-Mu with the hydroxyl end group, the yield measured by UV spectrometer and chemical analysis is 58% for 5-Fu and 41.3% for N-Mu respectively. The structure of these drugs are characterized by IR and NMR in detail.

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