A highly stereocontrolled approach to 3-methoxyestra-1,3,5(10),14-tetraen-17α-ol, an important intermediate for the synthesis of C(14)-substituted steroid derivatives-Science-Chemical Encyclopedia-lookchem

A highly stereocontrolled approach to 3-methoxyestra-1,3,5(10),14-tetraen-17α-ol, an important intermediate for the synthesis of C(14)-substituted steroid derivatives
Add time:08/05/2019 Source:sciencedirect.com

A four-step reaction sequence including (1) hydroxyl group-assisted epoxidation, (2) Jones oxidation, (3) DIBAH-reduction, and (4) epoxide deoxygenation has been devised in order to effect epimerization of 4 to 1, the overall yield approaching 65%.

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