Add time:08/02/2019         Source:sciencedirect.com

A series of six aromatic esters of both 5‐dimethyl‐amino‐1‐phenyl‐3‐pentanol and 3‐dimethylamino‐1‐(2‐phenylcy‐clohexyl)‐1‐propanol was prepared. Antimicrobial evaluation showed that the cyclic analogs had approximately twice the activity of the open chain series; in particular, the o‐chlorophenyl ester showed pronounced activity against three pathogenic fungi at approximately 10 ppm. Aromatic esters of 3‐dimethylamino‐1‐phenyl‐1‐propanol were prepared and demonstrated lower activity than two esters of 2‐dimethylamino‐1‐phenylcyclohexanol. The screening results showed that the best activity was found when a dimethylene chain was present between the phenyl ring and the carbon atom bearing the acyloxy function and that the cyclic derivatives were more active than their more flexible counterparts.

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