Add time:08/05/2019         Source:sciencedirect.com

The in vitro effect of 4-hydroxylaminoquinoline 1-oxide (4-HAQO) on bacteriophage T4 was investigated. Among five derivatives of 4-nitroquinoline 1-oxide (4-NQO), only 4-hydroxylaminoquinoline 1-oxide produced marked inactivation of the phage.This inactivation effect took place at pH > 7·0 and only in the presence of oxygen. Under these conditions, 4-HAQO lost its effect within 10 min.Spectrophotometric and chemical investigations established that 4-HAQO was oxidized to 4,4′-azoxyquinoline-1,1′-dioxide, indicating the existence of 4-nitrosoquino-line 1-oxide as an intermediate. This led to the conclusion that 4-HAQO itself is not the ultimate compound in the inactivation process of the phage but that an oxidation product is responsible for this event.The target of the chemical agent in the phage particle is not the tail protein but its DNA.Evidence for this is presented and the possible connection between these events and the initial step of carcinogenesis by 4-HAQO is discussed.

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