Add time:08/05/2019         Source:sciencedirect.com

The metabolic disposition of [14C]-labelled 4-chlorodiphenyl ether (4-CDE) was examined in the winter skate (Raja ocellata). Following intravenous administration of a single dose of 4-CDE (68 nmol/kg wet body wt.) to the skate, 4-CDE concentrations in the blood declined exponentially with time. Radioactivity was detected in all the organs and tissues examined; the liver and bile containing the highest levels. These results indicated that 4-CDE was removed rapidly from the blood by the tissues of the skate. The toxicokinetics of [14C]4-CDE in the skate were best described by a three-compartment open model with the central compartment and one of the peripheral compartments representing the blood and liver, respectively, of the skate. The validity of the model was confirmed by the observation that the apparent volume of the central compartment was identical to the blood volume of the skate and the liver accumulated the highest concentration of unmetabolized 4-CDE. 4-CDE was eliminated slowly from the skate mainly as metabolites in the bile. The body clearance of 4-CDE in the skate was 4.0 ± 1.1 ml · min−1 · kg−1 wet body wt.

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